Versatility of RNA-Binding Proteins in Cancer
نویسندگان
چکیده
منابع مشابه
Versatility of RNA-Binding Proteins in Cancer
Posttranscriptional gene regulation is a rapid and efficient process to adjust the proteome of a cell to a changing environment. RNA-binding proteins (RBPs) are the master regulators of mRNA processing and translation and are often aberrantly expressed in cancer. In addition to well-studied transcription factors, RBPs are emerging as fundamental players in tumor development. RBPs and their mRNA...
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1 Istituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche (IGM-CNR), Via Abbiategrasso 207, 27100 Pavia, Italy 2Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA 3Department of Human Genetics, National Health Institute Dr. Ricardo Jorge, 1649-016 Lisbon, Portugal 4Laboratory of Cellular and Molecul...
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Background: Trypanosomes mostly control gene expression by post-transcriptional events such as modulation of mRNA stability and translational efficiency. These mechanisms involve RNAbinding proteins (RBPs), which associate with transcripts to form messenger ribonucleoprotein (mRNP) complexes. Results: In this study, we report the identification of mRNA targets for Trypanosoma cruzi U-rich RBP 1...
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ژورنال
عنوان ژورنال: Comparative and Functional Genomics
سال: 2012
ISSN: 1531-6912,1532-6268
DOI: 10.1155/2012/178525